Cytoprotective effect of adenosine monophosphate against indomethacin – induced ulcer in albino rats. – G. O .Oze and H. U. Nwanjo
Gastric ulceration induced with 30mg/kg indomethacin was inhibited by 1mg/kg adenosine monosphosphate (AMP) in albino rats. The mean ulcer score was significantly reduced in both AMP treated rats (4.8 ± 0.41) and cemitidine treated rats (9.0 ± 0.71) p<0.05) “when compared with the control (31.60 ± 2.17). the degree of ulceration also followed the same pattern. The results indicate that adenosine monophosphate may play physiological role as a cytoprotective agent.